HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl acetate hexane → HCID 21948904, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Reactant | HCID 21948853 | HCID 21948853 | — |
| Reactant | Boron tribromide dichloromethane | HCID 22277759 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 21948904 | HCID 21948904 | 66.7% |
Reaction Steps
Analogously to Example 35, 153 mg (0.34 mmol) of 4-(5-fluoro-2-methoxyphenyl)-4-methyl-1-(2-methylquinolin-5-ylamino)-2-(trifluoromethyl)-pentan-2-ol in 17 ml of CH2Cl2 is reacted with 6.8 ml of 1M boron tribromide-CH2Cl2 solution. After chromatography on silica gel with hexane-ethyl acetate (0-55%), 99 mg of the product is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897224B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-27715d691895476999f505c114da097f |
| Source note | uspto-grants-2005_05 |