HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 2-Acetoxy-3-methoxybenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | o-Vanillin | HCID 8991 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Acetoxy-3-methoxybenzaldehyde | HCID 251703 | 74% |
Reaction Steps
Acetic anhydride (45.9 g, 0.45 mol) was added to a suspension of 3-methoxysalicylaldehyde (45.6 g, 0.3 mol) and K2CO3 (42.0 g, 0.6 mol) in CH2Cl2 (450 L) at rt. The reaction mixture was stirred at rt overnight then filtered, evaporated and the residue was recrystallised from cyclohexane to give 42 (42.0 g, 74%) as colourless needles:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08198302B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-e4efdb52c67c4a0e99b2eef199743808 |
| Source note | uspto-grants-2012_06 |