反应详情

1-(10-Aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-trien-10-yl)-2,2,2-trifluoro-ethanone (530 mg, 2.1 mmol) was added to chlorosulfonic acid (2 mL, 30 mmol) and stirred for 5 minutes The mixture was quenched with ice, extracted with EtOAc, dried (Na2SO4), filtered and concentrated to provide an oil (640 mg, 87%) (TLC 30% EtOAc/hexanes Rf 0.15).

1. customwas quenched with ice
2. extractionextracted with EtOAc
3. dry with materialdried (Na2SO4)
4. filtrationfiltered
5. concentrationconcentrated