HRID2182819

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cn1cc(C(O)c2cn(C(c3ccccc3)(c3ccccc3)c3ccccc3)cn2)cc1C(=O)c1ccc(Cl)cc1

HCID22481044

未命名化合物

PRODUCTS

生成物

HCID22481054

未命名化合物

收率 91.2%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418406

未命名化合物

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution 2.2 g of (4-chloro-phenyl)-{4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-1-methyl-1H-pyrrol-2-yl}methanone in 50 mL of CH2Cl2 was stirred with 2.5 g of activated manganese dioxide overnight. The reaction was filtered and the filtrate was evaporated in vacuo to give 2.0 g of (4-chlorophenyl)-[1-methyl-4-(1-trityl-1H-imidazole-4-carbonyl)-1H-pyrrol-2yl]methanone. CI-MS m/z=556 (M++H).

WORKUP

后处理

filtrationThe reaction was filtered
customthe filtrate was evaporated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ee6f703721df4b17a9b06c3a10cdb866
来源数据集: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06897319B2
来源说明: uspto-grants-2005_05

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:11]([CH3:41])[CH:12]=[C:13]([CH:15]([OH:40])[C:16]3[N:17]=[CH:18][N:19]([C:21]([C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH:20]=3)[CH:14]=2)=[O:9])=[CH:4][CH:3]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:11]([CH3:41])[CH:12]=[C:13]([C:15]([C:16]3[N:17]=[CH:18][N:19]([C:21]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)[C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)[CH:20]=3)=[O:40])[CH:14]=2)=[O:9])=[CH:4][CH:3]=1