Methyl triflate → HCID 22481060, compound

Participants

Reaction Steps

A mixture of 0.64 g (2 mmol) of [5-(4-chlorobenzoyl)-1-methyl-1H-pyrrol-3-yl]pyridin-4-ylmethanone and 0.22 mL (2 mmol) methyl triflate was stirred for 16 h in 20 mL of CH2Cl2. The solvent was evaporated and the residue recrystallized from EtOAc to give 0.76 g (77% yield) of the title compound as a white solid: mp 113-114° C. ES-MS m/z=339 (M++H). 1H NMR (300 MHz, CDCl3) δ 4.0 (s, 3H); 4.55 (s, 3H), 7.32 (dd, 2H); 7.8 (m, 3H); 8.2 (dd, 2H); 9.0 (dd, 2H). Anal calc'd for: C19H16ClN2O2.CF3O3S. 0.2 H2O: C, 48.77; H, 3.35; N, 5.68; KF,0.73. Found: C, 48.91; H, 3.5; N, 5.57; KF,1.03.

Provenance & Evidence