Sodium Hydroxide → HCID 57939192, compound

HRID 218283Notes

Reaction equation

HRID 218283 reaction equation
[OH-].[Na+].[CH2:3]([O:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)[C:18]([O:20]C)=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]>CO>[CH2:3]([O:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)[C:18]([OH:20])=[O:19])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 57939218HCID 57939218, compound

Product 1

HCID 57939192HCID 57939192, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

600 μL of 1 N sodium hydroxide solution (600 μmol) are added portionwise to 112 mg of 21 (366 μmol) in methanol (4 mL). The solution is refluxed for two hours. After evaporating off the solvent, the reaction medium is acidified with 0.5 N HCl and extracted with DCM. 107 mg of the expected acid are obtained in the form of a white solid, i.e. a yield of 99%.

Workup

  1. temperatureThe solution is refluxed for two hours
  2. customAfter evaporating off the solvent
  3. extractionextracted with DCM

Sources & evidence

ORD record
ord-91e12e18c244496fa83f9f5555f323b9
Source dataset
uspto-grants-2012_06
Patent number
US08198420B2

Reaction notes

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