Sodium Bicarbonate → HCID 20786541, compound

Participants

Reaction Steps

A solution of 6-[2-(3,5-dimethyl-4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-ylmethanesulfinyl]-benzimdazole-1-sulfonyl}phenoxy)acetylamino]hexanoic acid 2-(3-nitro-benzenesulfonyl)ethyl ester (Intermediate 18, 420 mg, 0.45 mmol) and of NaHCO3 (42 mg, 0.49 mmol) in THF-H2O (6 mL-3 mL) was heated to 70° C. for 1 h. Then volatile materials were removed, the residual gummy oil was dissolved in CH2Cl2 and the mixture was filtered to remove un-dissolved solid. The filtrate was concentrated to dryness and the residual semi-solid was treated with diethyl ether to precipitate a solid which was briefly treated with CH3CN. The solid was collected from CH3CN suspension by filtration to give Compound 6 (170 mg 50%) as a white solid.

Provenance & Evidence