Ethanol, 2-[(3-nitrophenyl)sulfonyl]- → HCID 131724894, compound

Participants

Reaction Steps

A mixture of 4-(3-isopropylphenoxyactamido)butyric acid (Intermediate 24, 3.1 g, 11.1 mmol, 1.1 eq), 2-(3-nitrobenzenesulfonyl)ethanol (2.3 g, 10.0 mmol), and TsOH.H2O (0.5 g) in 100 mL of benzene was heated overnight to reflux temperature with a Dean-Stark trap. Thereafter the mixture was concentrated by evaporation and the resulting residual oil was purified by column chromatography (CH2Cl2 to 1% MeOH in CH2Cl2) to give Intermediate 25 (4.8 g, 97%) as a light yellow oil which solidified on standing.

Provenance & Evidence