Sodium Bicarbonate → HCID 131724896, compound

Participants

Reaction Steps

A solution of (2-(2-benzenesulfonyl-ethoxycarbonylmethoxy)-4-{2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}phenoxy)acetic acid 2-benzenesulfonyl-ethyl ester (Intermediate 30, 500 mg, 0.50 mmol) and NaHCO3 (90 mg, 1.10 mmol, 2.2 eq) in THF-H2O (6 mL-3 mL) was heated to 70° C. for 2 h. Thereafter volatile materials were removed by evaporation under reduced pressure and the residual semi-solid was briefly treated with MeOH-CH2Cl2 (1:1). The resulting solid was collected by filtration to give Compound 12 (300 mg, 74%) as an off-white solid.

Provenance & Evidence