Sodium Bicarbonate → HCID 20786509, compound

Participants

Reaction Steps

A solution of 2-[2-(3,5-dimethyl-4-{2-[3-methyl-4-(2,2,2-trifluoroethoxy)-pyridin-2-ylmethanesulfinyl]-benzimidazole-1-sulfonyl}-phenoxy)acetylamino]-pentanedioic acid bis-[2-(3-nitro-benzenesulfonyl)-ethyl]ester (Intermediate 34, 800 mg, 0.69 mmol) and NaHCO3 (120 mg, 1.41 mmol, 2.05 eq) in THF-H2O (6 mL-3 mL) was heated to 70° C. for 3 h. Thereafter volatile materials were removed by evaporation under reduced pressure, the residual semi-solid was treated with EtOAc, and the mixture was filtered to remove undissolved materials. The filtrate was concentrated to total volume of about 3 mL, and then diethyl ether was added to the mixture. A solid precipitate formed and was collected by filtration to give Compound 13 (400 mg, 73%) as an off-white solid.

Provenance & Evidence