Chlorosulfonic acid → 2-(Carboxymethoxy)-5-(chlorosulfonyl)benzoic acid

HRID 2182889Notes

Reaction equation

[C:1]([CH2:4][O:5][C:6]1[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])([OH:3])=[O:2].[Cl:15][S:16](O)(=[O:18])=[O:17].ClS(C1C=CC(OC)=C(C=1)C(O)=O)(=O)=O>>[C:1]([CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([S:16]([Cl:15])(=[O:18])=[O:17])=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])([OH:3])=[O:2]

Participants

Reactant 3

HCID 24638Chlorosulfonic acid

HCID 69461Benzoic acid, 2-(carboxymethoxy)-

HCID 1040075-Chlorosulphonyl-2-anisic acid

Product 1

HCID 224793462-(Carboxymethoxy)-5-(chlorosulfonyl)benzoic acid

Procedure

2-(Carboxymethoxy)-5-chlorosulfonyl-benzoic acid was synthesized by the reaction of 2-carboxymethoxy benzoic acid with chlorosulfonic acid using a method similar to the synthesis of Intermediate 6.

Sources & evidence

ORD record: ord-0718fb66b0894a7682218ff47421227d
Source dataset: uspto-grants-2005_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06897227B2

Reaction notes

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