Water → 5-{(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide Monohydrate

Participants

Reaction Steps

A solution of 5-{(1R)-4-cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazole-3-carboxamide (1.58 Kg, 4.86 mol) in tetrahydrofuran (15 liters) was heated to 40° C. and demineralised water (26 liters) was added to give a hazy solution. The mixture was allowed to cool to ambient temperature where it was stirred for 24 hours. The mixture was cooled to 52° C. and stirred for 1 hour. The precipitate was collected by filtration and dried in vacuo (38° C., 100 mbar) to afford the title compound as a colourless solid (1.37 Kg).

Provenance & Evidence