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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2182979Generated: October 30, 2026

Trifluoroacetic acid → HCID 59909852, compound

https://huagongshe.com/reaction/2182979

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 59909804HCID 59909804—
SolventDichloromethaneHCID 6344—
ProductHCID 59909852HCID 59909852104.9%

Reaction Steps

A solution of tert-butyl (3R)-6-cyclohexyl-3-[3-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)-1,2,4-oxadiazol-5-yl]hexanoate (Preparation 16a) (91 mg, 0.19 mmol) in dichloromethane (4 ml) was treated with trifluoroacetic acid (1 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 17 hours. The solvent was removed under reduced pressure and the residue azeotroped from toluene to afford the title compound as a beige solid (82 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06897306B2
Source datasetuspto-grants-2005_05
ORD IDord-4199b7173ee4484c9f862b493c625b97
Source noteuspto-grants-2005_05