HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1,3,3-Trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Methyl-2,2,6,6-tetrachlorocyclohexanol | HCID 18970952 | — |
| Reactant | 1,3-Dichloro-3-fluoro-7-oxabicyclo[4.1.0]heptane | HCID 18970966 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1,3,3-Trichloro-2-methyl-7-oxabicyclo[4.1.0]heptane | HCID 18970971 | 95.5% |
Reaction Steps
The same procedure was employed as for the preparation of 2e in Example 17: it was performed with 3.97 g (15.75 mmol) of crude alcohol 1j, 20 cm3 of distilled water and 2.4 g (60 mmol) of sodium hydroxide; reaction time was 1 h 15 min; ether extraction (5×40 cm3); 3.29 g of epoxide 2h were obtained having a 95.5% yield based on the ketone (macrobore GC purity>99%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05424460 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-dba446c7a9b44a30bf42149a03215cf5 |
| Source note | uspto-grants-1995_06 |