4-Nitrobenzaldehyde → HCID 131724897, compound

Participants

Reaction Steps

7-[2-(1-methyl-1-tert-butoxycarbonylethoxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]-3-chloromethyl-3-cephem-4-carboxylic acid benzhydryl ester (775 mg, 0.8 mmol), sodium iodide (120 mg, 0.8 mmol), triphenylphosphine (210 mg, 0.8 mmol), 4-nitrobenzaldehyde (483 mg, 3.2 mmol) and sodium hydrogen carbonate (200 mg, 2.4 mmol) were used to conduct the procedure similar to that shown in (1) of Example 1 to obtain 568 mg (yield: 66%) of 7-[2-(1-methyl-1-tert-butoxycarbonylethoxyimino)-2-(2-tritylaminothiazol-4-yl)acetamido]-3-(4-nitrostyryl)-3-cephem-4-carboxylic acid benzhydryl ester as yellow powder.

Provenance & Evidence