4-Nitrobenzaldehyde → HCID 131724901, compound

Participants

Reaction Steps

7-[2-methoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-chloromethyl-3-cephem-4-carboxylic acid benzhydryl ester (395 mg, 0.47 mmol), sodium iodide (70 mg, 0.47 mmol), triphenylphosphine (123 mg, 0.47 mmol), 4-nitrobenzaldehyde (284 mg, 1.88 mmol) and sodium hydrogen carbonate (120 mg, 1.4 mmol) were used to conduct the procedure similar to that shown in (1) of Example 1 to obtain 242 mg (yield: 55%) of 7-[2-methoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-(4-nitrostyryl)-3-cephem-4-carboxylic acid benzhydryl ester as yellow powder.

Provenance & Evidence