Sodium Iodide → HCID 131724903, compound

Participants

Reaction Steps

7-[2-tert-butoxycarbonylmethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-chloromethyl-3-cephem-4-carboxylic acid benzhydryl ester (500 mg, 0.53 mmol), 2,4-dinitrobenzaldehyde (416 mg, 2.12 mmol), sodium iodide (79.4 mg, 0.53 mmol), triphenylphosphine (139 mg, 0.53 mmol) and sodium hydrogen carbonate (133.6 mg, 1.59 mmol) were used to conduct the procedure similar to that shown in (1) of Example 1 to obtain 350 mg (yield: 61%) of 7-[2-carboxymethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-(2,4-dinitrostyryl)-3-cephem-4-carboxylic acid benzhydryl ester as yellow powder.

Provenance & Evidence