4-Nitrobenzaldehyde → HCID 131724906, compound

Participants

Reaction Steps

7-[2-tert-butoxycarbonylmethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-chloromethyl-3-cephem-4-carboxylic acid benzhydryl ester (470 mg, 0.5 mmol), sodium iodide (75 mg, 0.5 mmol), triphenylphosphine (131 mg, 0.5 mmol), 4-nitrobenzaldehyde (302 mg, 2 mmol) and sodium hydrogen carbonate (126 mg, 1.5 mmol) were used to conduct the procedure similar to that shown in (1) of Example 1 to obtain 260 mg (yield: 50%) of 7-[2-carboxymethoxyimino-2-(2-tritylaminothiazol-4-yl)acetamido]-3-(4-nitrostyryl)-3-cephem-4-carboxylic acid benzhydryl ester as yellow powder.

Provenance & Evidence