HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrostyrene → 5-[(1E)-2-(3-Nitrophenyl)vinyl]-3-(4-fluorophenyl)-1H-indazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrostyrene | HCID 68514 | — |
| Reactant | 5-bromo-3-(4-fluorophenyl)-1H-indazole | HCID 22480293 | — |
| Product | 5-[(1E)-2-(3-Nitrophenyl)vinyl]-3-(4-fluorophenyl)-1H-indazole | HCID 22480184 | 52% |
Reaction Steps
The title compound (0.134 g, 52% yield) was prepared as described in Example 132 D, using 5-bromo-3-(4-fluorophenyl)-1H-indazole (0.291 g, 1.0 mmol) and 3-nitrostyrene (0.298 g, 2.0 mmol). 1H NMR (CDCl3) δ 10.12 (br s, 1H), 8.41 (t, 1H), 8.11 (ddd, 1H), 8.07 (s, 1H), 7.97 (m, 2H), 7.82 (d, 1H), 7.73 (dd, 1H), 7.54 (m, 2H), 7.40 (d, 1H), 7.26 (m, 2H), 7.16 (d, 1H); ES-MS (m/z) 360 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06897231B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-d7b3d6cb1df74a098b8cc44f85689540 |
| Source note | uspto-grants-2005_05 |