Succinic Acid → HCID 10459010, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.312 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.890 mmoles) and 0.695 g succinic acid (5.890 mmoles) in 50 ml isopropanol is heated to 80° C. The resulting almost clear solution is stirred at 80° C. Crystallization takes place spontaneously after ca. 5 minutes. The suspension is allowed to cool slowly and stirred at room temperature for 18 hours. The salt is collected after filtration and washing with 7 ml isopropanol. The crystals are dried for 20 hours at 70° C. and ca. 10 mbar.

Provenance & Evidence