Fumaric Acid → 1000160-87-1

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.208 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.625 mmoles) in 20 ml methanol is heated to 50° C. A solution of 0.326 g fumaric acid (2.81 mmoles) in 5 ml methanol is dropwise added to the suspension at constant flow rate, over 10 minutes. The resulting solution is stirred at 50° C. Crystallization takes then spontaneously place after ca. 10 minutes. The suspension is allowed to cool and stirred for 3 hours at room temperature. The mixture is filtered. The crystals are washed with 7 ml methanol and dried first for 20 hours at 60° C. and ca. 10 mbar and further for 2 h at 60° C. and ca. 1 mbar. Yield: 2.19 g white powder (86.4%)

Provenance & Evidence