2,3-Dihydroxybutanedioic Acid → HCID 10053080, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.0 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.10 mmoles) in 14 ml isopropanol is heated at 50° C. Then a solution of 0.77 g L (+) tartaric acid (5.10 mmoles) in 7.7 ml isopropanol is dropwise added over ca. 2 minutes. The suspension is stirred at 50° C. for 15 hours. The white suspension is cooled to ca. 25° C. and filtered. The salt is washed with 10 ml isopropanol and dried for 18 hours/50° C./ca. 10 mbar and for 2 hours at 60° C./ca. 1 mbar. Yield: 2.33 g white powder (84.27%)

Provenance & Evidence