Hydrochloric Acid → HCID 11553721, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 3.78 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (9.63 mmoles) in 36.5 ml methanol is heated to 50° C. A solution of 0.949 g hydrochloric acid 37% (9.63 mmoles) in 10 ml methanol is added dropwise, over 15 minutes. The resulting clear solution is allowed to cool. Crystallization begins spontaneously at 40° C. The suspension is stirred at room temperature for 17 hours. After filtration the salt is washed with 7 ml methanol. The crystals are dried for 16 hours at 50° C./ca. 10 mbar and for 2 hours at 50° C. and ca. 1 mbar. Yield: 2.33 g white powder (84.27%)

Provenance & Evidence