Hydrogen Bromide → HCID 68876933, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.93 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (4.92 mmoles) in 13.5 ml methanol is heated to 50° C., A solution of 0.829 g hydrobromic acid 48% (4.92 mmoles) in 5 ml methanol is dropwise added over 15 minutes. The resulting very thick suspension is diluted with 43 ml methanol and allowed to cool. After stirring for 3 hours at room temperature the precipitate is filtered. The filter cake is washed with 5 ml methanol. The crystals are dried for 16 hours at 50° C./ca. 10 mbar and for 2 hours at 50° C. and ca. 1 mbar. Yield: 2.33 g white powder (84.27%)

Provenance & Evidence