Formic Acid → HCID 24178417, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.00 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.1 mmoles) in 15 ml methanol is heated to 50° C. 0.24 g formic acid (5.2 mmoles) are dropwise added. The dropping funnel is rinsed with 5 ml methanol. The resulting clear solution is allowed to slowly cool. Crystallization starts spontaneously at ca. 47° C. The mixture is stirred at ca. 25° c. for 15 hours and filtered. The filter cake is washed with 4 ml methanol. The salt is dried for 20 hours at 50° C./ca. 10 mbar and for 3 hours at 70° C. and ca. 1 mbar. Yield: 1.77 g white powder (79.37%)

Provenance & Evidence