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Hydrochloric Acid → 3-Chloro-2-vinylphenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,3,3-Trichloro-2-vinyl-7-oxabicyclo[4.1.0]heptane | HCID 18970949 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Chloro-2-vinylphenol | HCID 18970955 | 75.4% |
反応手順
0.84 g (3.69 mmol) of epoxide 2i in solution in 4 cm3 of anhydrous DMF were heated to reflux for 3 h 30 min. The solution was acidified (pH=1) with 3N HCl, extracted with ether (4×20 cm3), dried over MgSO4, filtered and evaporated down. The crude product obtained was purified by flash chromatography on silica (eluent: ether/petroleum ether=5/95). 0.43 g of phenol 4f were obtained (macrobore GC purity>99%). The yield of compound 4f was 75.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424460 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-8925bd503a8e4c209a12c8bb9fb832aa |
| 出典メモ | uspto-grants-1995_06 |