p-Toluenesulfonic acid monohydrate → HCID 24178419, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.00 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.1 mmoles) and 0.98 g p-toluenesulfonic acid monohydrate (5.1 mmoles) in 30 ml ethylacetate is heated to 60° C. During heating the initially sticky yellow amorphous mass, turns to a white, good stirrable suspension. The suspension is allowed to cool and stirred at room temperature over night. The crystals are collected after filtration and washing with ethylacetate. The salt is dried for ca. 20 hours at 50° C. and ca. 10 mbar. Yield: 2.73 g off white powder (94.8%)

Provenance & Evidence