Glycolic Acid → HCID 24178423, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.075 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.286 mmoles) in 25 ml methanol is heated to 50° C. A solution of 0.402 g glycolic acid (5.286 mmoles) in 5 ml methanol is added dropwise over 7 minutes. The resulting clear solution is stirred at 50° C. Crystallization takes spontaneously place after ca 15 minutes. The white suspension is allowed to cool to room temperature and stirred over night at ca. 25° C. After 18 hours the salt is filtered. The filter cake is washed with 7 ml methanol and dried first 20 hours at 60° C. and ca. 10 mbar and then 2 hours at 60° C. and ca. 1 mbar.

Provenance & Evidence