Acetic Acid → Indacaterol acetate

Participants

Reaction Steps

2.168 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.523 mmoles) and 1.17 g acetic acid (19.48 mmoles) are dissolved in 60 ml isopropanol at 80° C. The clear solution is allowed to cool slowly. Crystallization takes place spontaneously at 35° C. The suspension is stirred for 17 hours at room temperature and then filtered. The filter cake is washed with 10 ml isopropanol and dried at 60° C./ca 10 mbar for 20 hours.

Provenance & Evidence