Water → 7-Dehydrositosterol

Participants

Reaction Steps

To a solution of 7-dehydrositosterol acetate (6) (2.5 g, 5.5 mmol) in dry ether (200 mL) was added lithium aluminum hydride (2.09 g, 55.0 mmol). The reaction mixture was stirred at room temperature for 2 h, then cooled with an ice-water bath and the excess water (5 mL). After 30 minutes, ether (100 mL) was added and filtered. The cake was washed with ether (2×100 mL) and the combined organic extracts were dried (MgSO4), filtered and concentrated in vacuo to afford 7-dehydrositosterol (7) in quantitative yield.

Provenance & Evidence