Malonic Acid → HCID 24178421, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 2.172 g (R)-5-[2-(5,6-diethyl-indan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-1H-quinolin-2-one base (5.533 mmoles) und 0.576 g malonic acid (5.533 mmoles) in 25 ml n-butanol is heated to 80° C. Initially an oil formed during heating, which crystallizes on prolonged heating. The mixture is stirred at 80° C. for 15 minutes and then allowed to cool to room temperature. The suspension is stirred for 18 hours at room temperature. After filtration the crystals are washed with 5 ml n-butanol and 10 ml acetone. The product is dried at 70° C. and 70° C. for 20 hours. Yield: 2.62 g white powder (95.28%)

Provenance & Evidence