Hydrochloric Acid → HCID 86759746, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 30 g (126 mmol) 4-(trifluoromethoxy)-1,1′-biphenyl and 21 g aluminium trichloride (157 mmol) in 120 ml nitrobenzene are added at a temperature below 20° C. 9.87 g (126 mmol) acetyl chloride. The reaction mixture is stirred for 2 h at 0° C., added to 240 ml ice-water and 42 ml conc. HCl and extracted with ethyl acetate. The organic phase is washed with water and brine and the solvents removed in vacuo. The residue is triturated with petrol ether, filtrated and dried. From the filtrate another batch can be obtained after crystallizing at 4° C. to give overall 23.5 g (66%).

Provenance & Evidence