3-(2-Fluorophenyl)prop-2-enoic acid → (S)-3-(2-fluoro-phenyl)-N-{1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethyl}-acrylamide

HRID 2183469Notes

Reaction equation

HRID 2183469 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([OH:8])=O.[CH3:13][C:14]1[N:19]=[CH:18][C:17]([O:20][C:21]2[CH:22]=[C:23]([C@@H:27]([NH2:29])[CH3:28])[CH:24]=[CH:25][CH:26]=2)=[CH:16][CH:15]=1>>[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH:4]=[CH:5][C:6]([NH:29][C@H:27]([C:23]1[CH:24]=[CH:25][CH:26]=[C:21]([O:20][C:17]2[CH:18]=[N:19][C:14]([CH3:13])=[CH:15][CH:16]=2)[CH:22]=1)[CH3:28])=[O:8]

Participants

3

Reactant 2

HCID 679773-(2-Fluorophenyl)prop-2-enoic acidHCID 60004124(S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine

Product 1

HCID 69796642(S)-3-(2-fluoro-phenyl)-N-{1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethyl}-acrylamide

Procedure

The title compound was prepared from 2-fluorocinnamic acid following the general procedures as described for Example 1 with the exception that (S)-1-[3-(6-methyl-pyridin-3-yloxy)-phenyl]ethylamine was used.

Sources & evidence

ORD record
ord-5346e04c226c4b249be80be9acb858df
Source dataset
uspto-grants-2005_05
Patent number
US06900210B2

Reaction notes

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