HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 69797247, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-(3-Chlorophenyl)prop-2-enoic acid | HCID 74631 | — |
| Reactant | HCID 60004113 | HCID 60004113 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69797247 | HCID 69797247 | 65.1% |
Reaction Steps
A mixture of (s)-[3-(1-amino-ethyl)-phenyl]-pyridin-3-ylmethyl-amine (0.2 mmol), 3-chlorocinnamic acid (0.2 mmol), EDACeHCl (0.4 mmol), DMAP (0.2 mmol), triethylamine (0.6 mmol) in dichloromethane (4 mL) was stirred at 5 room temperature for 12 h. The reaction mixture was purified by flash chromatography eluting with 5% methnol in ethyl acetate to provide the desired title compound (51 mg) as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900210B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-b3c35211956f49c8a79f170038f664e4 |
| Source note | uspto-grants-2005_05 |