HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalazine → 6-[5(Tert-butyldimethylsilyloxymethyl)pyridin-2-ylmethyloxy]-3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-alpha]phthalazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalazine | HCID 9207 | — |
| Reactant | 3-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-5-methylisoxazole | HCID 18427539 | — |
| Reactant | 5-(tert-Butyldimethylsilyloxymethyl)-2-(hydroxymethyl)pyridine | HCID 22473222 | — |
| Product | 6-[5(Tert-butyldimethylsilyloxymethyl)pyridin-2-ylmethyloxy]-3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-alpha]phthalazine | HCID 131724933 | — |
Reaction Steps
The reaction was carried out as described in Example 1, Step 4 using 5-(tert-butyldimethylsilyloxymethyl)-2-(hydroxymethyl)pyridine (1.0 g, 3.95 mmol) and 6-chloro-3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-α]phthalazine (1.12 g, 3.95 mmol) to give, after column chromatography on silica using 2-3% MeOH/CH2Cl2 as eluent, the title phthalazine (1.4 g, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900209B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-8d8b2b6714ed41a2a704aa8eef6c5ea0 |
| Source note | uspto-grants-2005_05 |