HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-5-methylisoxazole → 1-Methyl-1-{2-[3-(5-methylisoxazol-3-yl)[1,2,4]triazolo[3,4-alpha]phthalazin-6-yloxymethyl]pyridin-5-yl}ethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-5-methylisoxazole | HCID 18427539 | — |
| Reactant | (5-(2-Aminopropan-2-yl)pyridin-2-yl)methanol | HCID 69793455 | — |
| Product | 1-Methyl-1-{2-[3-(5-methylisoxazol-3-yl)[1,2,4]triazolo[3,4-alpha]phthalazin-6-yloxymethyl]pyridin-5-yl}ethylamine | HCID 69895504 | — |
Reaction Steps
The reaction was carried out as described in Example 1, Step 4 using 1-[2-(hydroxymethyl)pyridin-5-yl](1-methyl)ethylamine (330 mg, 1.98 mmol) and 6-chloro-3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-α]phthalazine to give after column chromatography on silica, eluting with 4% MeOH/CH2Cl2 containing 1% NH3 solution, the title compound (504 mg, 61%) which was recrystallised from CH2Cl2/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06900209B2 |
| Source dataset | uspto-grants-2005_05 |
| ORD ID | ord-d33be2775d984a96b913b2ba1a12a3dc |
| Source note | uspto-grants-2005_05 |