Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 70098057, compound

Participants

Reaction Steps

A solution of 6-({[1-(2-{[(dimethylethyl)(dimethyl)silyl]oxy}ethyl)-1H-[1,2,3]triazol-5-yl]methyl}oxy)-3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-α]phthalazine (606 mg, 1.2 mmol) and pyridinium para-toluenesulfonate (602 mg, 2.4 mmol) in EtOH (100 ml) was heated at 70° C. for 36 h. The reaction was cooled to room temperature and concentrated to approximately 25 ml, the resulting solid was filtered off and dried to yield the desired phthalazine (429 mg, 91%). 1H NMR (360 MHz, d6-DMSO) δ 8.55 (1H, d, J=8.0 Hz), 8.22 (1H, d, J=8.0 Hz), 8.12-8.00 (2H, m), 7.93 (1H, t, J=8.0 Hz), 7.11 (1H, s), 5.83 (2H, s), 4.58 (2H, t, J=5.3 Hz), 3.84 (2H, t, J=5.3 Hz), 2.59 (3H, s).

Provenance & Evidence