Trifluoroacetic acid → HCID 131724943, compound

Participants

Reaction Steps

The reaction was carried out according to Example 12 step 3 using 1,1-dimethylethyl 5-({[3-(5-methylisoxazol-3-yl)[1,2,4]triazolo[3,4-α]phthalazin-6-yl]oxy}methyl)-3′6′-dihydro-2,4′-bipyridine-1′(2′H)-carboxylate (296 mg, 0.55 mmol) and trifluoroacetic acid (5 ml). The crude residue was purified by column chromatography on silica using 7% MeOH/CH2Cl2 containing 1% NH3 to yield the desired phthalazine (124 mg, 51%). 1H NMR (360 MHz, CDCl3) δ 8.81 (1H, s), 8.68 (1H, d, J=7.6 Hz), 8.21 (1H, d, J=8.0 Hz), 8.05-7.90 (2H, m), 7.80 (1H, t, J=8.0 Hz), 7.43 (1H, t, J=8.1 Hz), 6.85 (1H, s), 6.75 (1H, broad s), 5.68 (2H, s), 3.60 (2H, q, J=2.9 Hz), 3.12 (2H, t, J=5.7 Hz), 2.67-2.55 (5H, m). m/z (ES+) 440 (M+H+).

Provenance & Evidence