反应详情

温度

99 °C

6-Aminouracil (14.32 g, 112.7 mmol) was added to glacial acetic acid (112.5 mL) and water (75 mL) and the mixture heated to 99° C. A solution of methyl 5-[(2E)-3-(dimethylamino)prop-2-enoyl]-2-methoxybenzoate (15 g, 56.3 mmol) in DMSO (75 mL) was then added over 180 minutes. The reaction was stirred at 99° C. for a further 90 minutes and cooled to 60° C. Water (75 mL) was then added and the reaction maintained at 60° C. for a further 60 minutes and then filtered off to afford a beige solid. The solid was washed with fresh water (75 mL) and dried visibly dry thus affording 19.6 g of water wet solid (9).

1. temperaturecooled to 60° C
2. temperaturethe reaction maintained at 60° C. for a further 60 minutes
3. filtrationfiltered off
4. customto afford a beige solid
5. washThe solid was washed with fresh water (75 mL)
6. customdried visibly
7. customdry thus