3-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-5-methylisoxazole → HCID 131724946, compound

Participants

Reaction Steps

The reaction was carried out according to Example 1 step 4 using (6-vinylpyridin-3-yl)methanol (500 mg, 3.7 mmol) and 6-chloro-3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-α]phthalazine (1.05 g, 3.7 mmol). The crude residue was purified by column chromatography on silica using 2-4% MeOH/CH2Cl2 to yield the desired phthalazine (1.31 g, 92%). 1H NMR (360 MHz, CDCl3) δ 8.86 (1H, s), 8.68 (1H, d, J=8.0 Hz), 8.21 (1H, d, J=8.0 Hz), 8.03 (1H, dd, J=8.0, 2.2 Hz), 7.95 (1H, t, J=8.0 Hz), 7.80 (1H, t, J=8.0 Hz), 7.40 (1H, d, J=8.0 Hz), 6.88-6.78 (2H, m), 6.23 (1H, dd, J=17.5, 1.1 Hz), 5.68 (2H, s), 5.51 (1H, dd, J=10.8, 1.1 Hz), 2.59 (3H, s). m/z (ES+) 385 (M+2H+).

Provenance & Evidence