HCID 21250141, compound → HCID 10180424, compound

HRID 2183527Notes

Reaction equation

HRID 2183527 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]2=[N:12][N:13]=[C:14]([C:15]3[O:19][N:18]=[C:17]([CH3:20])[N:16]=3)[N:4]2[N:3]=1.[CH3:21][N:22]([CH3:32])[CH2:23][CH2:24][N:25]1[C:29]([CH2:30][OH:31])=[N:28][CH:27]=[N:26]1>>[CH3:21][N:22]([CH3:32])[CH2:23][CH2:24][N:25]1[C:29]([CH2:30][O:31][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]3=[N:12][N:13]=[C:14]([C:15]4[O:19][N:18]=[C:17]([CH3:20])[N:16]=4)[N:4]3[N:3]=2)=[N:28][CH:27]=[N:26]1

Participants

3

Reactant 2

HCID 21250141HCID 21250141, compoundHCID 22473217HCID 22473217, compound

Product 1

HCID 10180424HCID 10180424, compound

Procedure

The reaction was carried out using the procedure described in Example 1, Step 4 using 6-chloro-3-(3-methyl[1,2,4]oxadiazol-5-yl)-[1,2,4]triazolo[3,4-α]phthalazine (WO-A-9850385) (125 mg, 0.44 mmol) and [2-(2-dimethylaminoethyl)-2H-[1,2,4]triazol-3-yl]methanol (Example 4, Step 2) (74 mg, 0.44 mmol). Crude residue was purified on silica, eluting product with 3% MeOH/DCM, followed by trituration with DCM and isohexane. The title compound was isolated by filtration to give a white solid (50 mg, 27%).

Workup

  1. customCrude residue was purified on silica
  2. washeluting product with 3% MeOH/DCM

Sources & evidence

ORD record
ord-2d80f80e859e4f1abd43eebef08700c4
Source dataset
uspto-grants-2005_05
Patent number
US06900209B2

Reaction notes

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