HCID 131724952, compound → HCID 131724953, compound

Participants

Reaction Steps

A mixture of [1-methyl-5-({[3-(5-methylisoxazol-3-yl)-[1,2,4]triazolo[3,4-α]phthalazin-6-yl]oxy}methyl]-1H-[1,2,4]triazol-3-yl}methanol (Example 20) (1 g, 2.55 mmol) in chloroform (120 ml) and manganese dioxide (4.4 g, 51 mmol) was heated at reflux for 60 h. More manganese dioxide (2.2 g, 25 mmol) was added and reflux continued for further 24 h. The cooled mixture was filtered through “Hyflo” eluting with chloroform. Solvent was evaporated in vacuo to give the crude carbaldehyde as a yellow solid (320 mg). MS (ES+) 391 (M+1).

Provenance & Evidence