3-Pentanol → HCID 10269405, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 60% Sodium hydride in oil (160 mg) in 4 ml of DMSO was added 3-pentanol (853 mg), and then 7-chloro-2,5-dimethyl-3-(2,4,6-trimethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (580 mg) at room temperature. The mixture was heated at 88° C. overnight. The mixture was quenched with water and extracted with ethyl acetate. The organic layer was dried and concentrated and purified through silica gel column chromatography using 10% hexane in chloroform as eluent to give the title compound as an orange oil. 1H NMR (CDCl3) ä 6.96(s, 2H), 5.95(s, 1H), 4.52(m, 1H), 2.48(s, 3H), 2.33(s, 3H), 2.27(s, 3H), 2.03(s, 6H), 1.75-2.00(m, 4H), 1.08(t, 6H)ppm.

Provenance & Evidence