Phosphoric Acid → HCID 69032043, compound

HRID 218354Notes

Reaction equation

HRID 218354 reaction equation
[CH3:1][C@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[N:9]=[C:10]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][C@@H:29]2[CH3:34])[C:11]2[CH:17]=[CH:16][C:15]([C:18]3[CH:19]=[CH:20][C:21]([O:26][CH3:27])=[C:22]([CH2:24][OH:25])[CH:23]=3)=[N:14][C:12]=2[N:13]=1.[P:35](=O)([OH:38])([OH:37])[OH:36]>CC#N>[P:35]([O:25][CH2:24][C:22]1[CH:23]=[C:18]([C:15]2[CH:16]=[CH:17][C:11]3[C:10]([N:28]4[CH2:33][CH2:32][O:31][CH2:30][C@@H:29]4[CH3:34])=[N:9][C:8]([N:3]4[CH2:4][CH2:5][O:6][CH2:7][C@@H:2]4[CH3:1])=[N:13][C:12]=3[N:14]=2)[CH:19]=[CH:20][C:21]=1[O:26][CH3:27])([OH:38])([OH:37])=[O:36]

Participants

4

Reactant 2

HCID 1004Phosphoric Acid2×HCID 25262965AZD 80552×

Product 1

HCID 69032043HCID 69032043, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

On a 50 mg scale using a 1:1.1 molar ratio of (5-{2,4-Bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol:Phosphoric acid. 50 mg of (5-{2,4-Bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol was dissolved in the minimal amount of MeCN, this solution was then added drop-wise to a vial containing the phosphoric acid which caused a yellow solid to immediately precipitate. The experiment was then left to stir over night at room temperature before filtering and isolating the precipitate.

Workup

  1. additionthis solution was then added drop-wise to
  2. customto immediately precipitate
  3. waitThe experiment was then left
  4. filtrationbefore filtering
  5. customisolating the precipitate

Sources & evidence

ORD record
ord-334290c7ce4745f488da4163bc774a65
Source dataset
uspto-grants-2012_06
Patent number
US08198441B2

Reaction notes

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