Methyl iodide → HCID 10137537, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [6-bromo-5-methyl-3-(2,4,6-trimethyl-phenyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-7-yl]-(1-ethyl-propyl)-amine (50 mg, 0.12 mmol) in dry THF )1.5 ml) was added 2.5 M n-BuLi in hexane (0.14 ml) at −78° C. After stirring at −78° C. for 10 min, 0.5 ml of methyl iodide was added at that temperature then allowed to warmed to room temperature and stirred for 15 min for 2 hours. The mixture was quenched with water and extracted with ethyl acetate. The organic layer was washed with brine, dried and concentrated to give 46 mg of brown oil. The residue was purified through silica gel coliumn chromatography using 1:1 chloroform:hexane as eluent to give the title compound as a golden oil. 1H NMR (CDCl3) ä 7.04(s, 2H), 4.35(m, 1H), 3.32(s, 3H), 2.70(s, 3H), 2.38(s, 3H), 1.94(s, 6H), 1.7-2.0(m, 4H), 1.01(t, 6H)ppm.

Provenance & Evidence