反应详情

温度

0 °C

A mixture of 2-bromo-1-(4-chlorobenzo[b]thiophen-2-yl]ethan-1-one (2.5 g), 2-imidazolidinethione (0.88 g), acetic acid (25 ml) and ethanol (50 ml) was heated under reflux for 90 minutes, then cooled to 0° C. The resulting solid was collected by filtration and dried in vacuo at 60° C. for 2 hours to give 3-(4-chlorobenzo[b]thiophen-2-yl)-5,6-dihydroimidazo[-2,1-b]thiazole hydrobromide (2.15 g) as colourless solid, m.p. 261-263° C.

1. temperaturewas heated
2. temperatureunder reflux for 90 minutes
3. filtrationThe resulting solid was collected by filtration
4. customdried in vacuo at 60° C. for 2 hours