反应详情

A mixture of 1-(benzo[b]thiophen-4-yl)-2-chloroethan-1-one (1.15 g), 2-imidazolidinethione (0.57 g), ethanol (10 ml) and acetic acid (6 ml) was heated under reflux for 18 hours then cooled to ambient temperature. The solvents were removed in vacuo and the residue was triturated with ether (30 ml). The resulting solid was collected by filtration, washed with ether (30 ml) and dried in vacuo at 40° C. to give 3-(benzo[b]thiophen-4-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride (1.73 g) as a cream solid, m.p. 246-249° C.

1. temperaturewas heated
2. temperatureunder reflux for 18 hours
3. customThe solvents were removed in vacuo
4. customthe residue was triturated with ether (30 ml)
5. filtrationThe resulting solid was collected by filtration
6. washwashed with ether (30 ml)
7. customdried in vacuo at 40° C.