Acetic Acid → HCID 9879812, compound

Participants

Reaction Steps

A mixture of 2-chloro-1-(4-fluorobenzo[b]thiophen-2-yl]ethan-1-one (0.16 g; prepared in a manner similar to that described above), 2-imidazolidinethione (0.071 g), acetic acid (10 ml) and ethanol (5 ml) was heated under reflux for 2 hours then cooled to ambient temperature. The solvents were removed in vacuo and the residue was triturated with ether (10 ml). The resulting solid was collected by filtration and dried in vacuo at 60° C. for 2 hours to give 3-(4-fluorobenzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrochloride (0.19 g) as pale pink solid, m.p. 220-224° C.

Provenance & Evidence