Acetic Acid → HCID 22474262, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromo-1-(4-fluorobenzo[b]thiophen-2-yl)propan-1-one (0.67 g), 2-imidazolidinethione (0.24 g), acetic acid (10 ml) and ethanol (5 ml) was heated under reflux for 2 hours then cooled to 20° C. The mixture was concentrated in vacuo and the resulting solid was collected by filtration, washed with ethanol (5 ml) and dried in vacuo at 60° C. for 2 hours to give 3-(4-fluorobenzo[b]thiophen-2-yl)-2-methyl-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (0.82 g) as beige solid, m.p. 224-226° C.

Provenance & Evidence