Sodium Carbonate → HCID 9943990, compound

HRID 2183633Notes

Reaction equation

HRID 2183633 reaction equation
C(=O)([O-])[O-].[Na+].[Na+].Br.[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2>ClCCl.O>[S:8]1[C:12]([C:13]2[N:14]3[CH2:20][CH2:19][N:18]=[C:15]3[S:16][CH:17]=2)=[CH:11][C:10]2[CH:21]=[CH:22][CH:23]=[CH:24][C:9]1=2

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 22474170HCID 22474170, compound

Product 1

HCID 9943990HCID 9943990, compoundYield 90.5%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

Sodium carbonate (9.29 g) was added at 0° C. to a stirred suspension of 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole hydrobromide (19.0 g) in a mixture of dichloromethane (300 ml) and water (300 ml). The mixture was stirred at ambient temperature for 3 hours, then the organic phase was separated, washed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml), dried (Na2SO4) and the solvents were removed in vacuo to give 3-(benzo[b]thiophen-2-yl)-5,6-dihydroimidazo[2,1-b]thiazole as a brown solid (13.1 g) which was used without further purification.

Workup

  1. customthe organic phase was separated
  2. washwashed with water (200 ml) and saturated aqueous sodium chloride solution (200 ml)
  3. dry with materialdried (Na2SO4)
  4. customthe solvents were removed in vacuo

Sources & evidence

ORD record
ord-6862eca620ff44419eb52980ee99c1a7
Source dataset
uspto-grants-2005_05
Patent number
US06900216B2

Reaction notes

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